HYPOCATALASIA
What is Hypocatalasia? Hypocatalasia is the deficiency of an enzyme called catalase in red blood cells. The catalase enzyme plays an important role in the cells defense against a type of chemical damage, known as oxidative damage. The disorder is characterized by ulcers and progressive gangrene (tissue death) of the mouth. Age of Onset is 0 to 2 yrs.
This is a disorder discovered in Beagles. Beagles were used in the make-up of the Rat Terrier breed. The American Hairless Terrier is a mutation which occurred from Rat Terriers. Hypocatalasia is also found in the AHT breed.
Inheritance is Autosomal Recessive. For autosomal recessive disorders, dogs with two copies of the variant are at risk of developing the condition. Dogs with one copy of the variant are called carriers, and although they are not at risk for development of the disorder, they may pass the disease variant on to their puppies if bred.
Likelihood of the Condition – Moderate. At risk dogs (carry 2 copies of the gene) may show signs of this disease in their lifetime, although some will not develop the condition due to absence of additional risk factors. |
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